CAS Number: 936563-96-1
Molecular Weight: 440.507
Method of Analysis:In house
Chronic Lymphocytic Leukemia (CLL), Mantle Cell Lymphoma (MCL)
Ibrutinib is a small-molecule inhibitor of BTK. Ibrutinib forms a covalent bond with a cysteine residue in the BTK active site, leading to inhibition of BTK enzymatic activity. BTK is a signaling molecule of the B-cell antigen receptor (BCR) and cytokine receptor pathways. BTK's role in signaling through the B-cell surface receptors results in activation of pathways necessary for B-cell trafficking, chemotaxis, and adhesion. Nonclinical studies show that ibrutinib inhibits malignant B-cell proliferation and survival in vivo as
well as cell migration and substrate adhesion in vitro.
stor in light-resistant and well closed container .protect from air and moisture ,at a temperature of 2-8ᵒC
The final product is packed in polyethylene nylon plastic bag and then packaged in a 3-layered aluminum foil.