CAS Number: 847871-99-2
Molecular Weight: 536.5
Method of Analysis:In house
multiple myeloma (MM), mantle cell lymphoma (MCL)
Cellular activities of lenalidomide are mediated through its target cereblon, a component of a cullin ring E3 ubiquitin ligase enzyme complex. In vitro, in the presence of drug, substrate proteins (including Aiolos, Ikaros, and CK1α) are targeted for ubiquitination and subsequent degradation leading to direct cytotoxic and immunomodulatory effects. Lenalidomide inhibits proliferation and induces apoptosis of certain hematopoietic tumor cells including MM, mantle cell lymphoma, and del (5q) myelodysplastic syndromes, follicular lymphoma and marginal zone lymphoma in vitro. Lenalidomide causes a delay in tumor growth in some in vivo nonclinical hematopoietic tumor models including MM.
preserve in well-closed containers, protect from light and moisture.store at room temprature.
The final product is packed in polyethylene nylon plastic bag and then packaged in a 3-layered aluminum foil.